Kinase(s)

 

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate; cytoplasmic threonine, receptor tyrosine kinases (RTKs), and serine/threonine.

The prominent roles that kinases play in cell division have made them attractive targets for both immunosuppressant drugs and cancer therapeutics. Kinases are highly druggable, and account for over 25% of targets screened by the pharmaceutical industry. Currently, there are over 25 kinase inhibitors that have been approved for clinical use by the FDA, including rapamycin, which was discovered in the 1960s. It was not until three decades later, however, that the target of rapamycin was discovered to be a serine/threonine kinase that was named mammalian target of rapamycin (mTOR). Today rapamycin is approved as an immunosuppressant and a number of mTOR inhibitors are being investigated as treatments for various forms of cancer.

BPS offers a wide selection of kinases, kinase substrates and kinase inhibitors. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays. We also offer kinase inhibitor screening services.

References:

1.   Cohen, P. Nat. Rev. Drug Disc. 2002; 1: 309-315.
2.   Ballou, L.M., et al., J. Chem. Biol. 2008 1(1-4): 27-36.
3.   Loewith, R., et al., Genetics. 2011; 189(4): 1177-1201.

 

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Catalog#SizeProduct NamePrice
40025 10 µg AMPK (A1/B1/G1), His-tags
$615
40701 5 µg AMPK (A1/B1/G2), His-tag
$480
40021 10 µg AMPK (A1/B1/G2), His-tags
$625
40702 5 µg AMPK (A1/B1/G3), His-tag
$480
40022 10 µg AMPK (A1/B1/G3), His-tags
$625
40703 5 µg AMPK (A1/B2/G1), His-tag
$480
40023 10 µg AMPK (A1/B2/G1), His-tags
$625
40704 5 µg AMPK (A2/ B1/G1), His-tag
$480
40024 10 µg AMPK (A2/B1/G1), His-tags
$625
40705 5 µg AMPK (A2/B2/G1), His-tag
$480
40026 10 µg AMPK (A2/B2/G1), His-tags
$625
40706 5 µg AMPK (A2/B2/G2), His-tag
$480
40027 10 µg AMPK (A2/B2/G2), His-tags
$625
40010 10 µg aRAF, His-tag
$365
40028 10 µg Ask1, GST-tag
$390
40520 1 mg ATF2, GST-tag
$270
79686 200 μl ATP (500 μM)
$205
40004 10 µg Aurora A Protein Kinase, His-Tag
$355
40178 10 µg AURORA C, GST-tag
$390
40002 10 µg Aurora Kinase B, GST-tag, His-tag
$355
27064 50 mg Axitinib
$80
79711 96 reactions AXL Kinase Assay Kit
$510
100174 10 µg AXL, FLAG-Tag
$355
40180 10 µg Axl, GST-tag
$355
48688 96 reactions B-Raf(V600E) Kinase Assay Kit
$510

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