Anti-CTLA4 Neutralizing Antibody
Catalog #
71212
$490
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Description
Neutralizing recombinant human monoclonal antibody recognizing the extracellular domain of CTLA4 and blocking binding of CTLA4 to B7.1 and B7.2. This antibody recognizes human CTLA4 but does not bind to murine CTLA4. This antibody has not been tested for cross-reactivity with other species
This product has been cited 3 times.
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Synonyms
Cytotoxic T-lymphocyte-associated protein 4, CD152, CTLA-4
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Product Data Gallery
CTLA4 B7-1 Interaction
Product Info
Storage and Usage
Citations3
Species
Human
Isotype
IgG1κ
Host Species/Expression System
Freestyle 293 cells
Purification
Protein A affinity chromatography
from HEK293 supernatants.
Format
Aqueous buffer solution.
Formulation
8 mM phosphate, 110 mM
NaCl, 2.2 mM KCl, pH 7.4, and 20%
glycerol
MW
150 kDa
Endotoxin Level
<1 EU/µg
Specific Activity
IC50 = 5 nM
UniProt #
P16410
References
1. Linsley, P.S., et al., J. Exp. Med. 1991; 174(3): 561-569.
2. Hurwitz, A.A., et al., Canc. Res. 2000; 60: 2444-2448.
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