Anti-CD28 Agonist Antibody (Humanized)
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Catalog #
100186
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$345
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Description
Recombinant agonist monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life.
This product has been cited 1 time.
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Synonyms
T-Cell-Specific Surface Glycoprotein, TP44
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Product Data Gallery
Costimulatory Activity of Anti-CD28 Antibody on IL-2 reporter/Jurkat Cells
Product Info
Storage and Usage
Citations1
Species
Human
Isotype
IgG1
Clonality
Monoclonal
Host Species/Expression System
HEK293
Purification
Protein A affinity chromatography from HEK293 supernatants.
Format
Aqueous buffer solution.
Formulation
8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol
MW
Heavy Chain: 50 kDa; Light Chain: 24 kDa
UniProt #
P10747
Background
The T cell-specific receptor CD28 is an important regulator of the immune system. The ligation of CD28 and its ligands CD80/CD86 on the APC provides a critical costimulatory signal alongside T cell receptor (TCR) for T cell activation. The costimulatory signal can also be delivered by the interaction between CD28 and its agonist antibody.
References
1. Takemura, S., et al., FEBS Letters, 2000; 476: 266-271.
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