Anti-CD28 Agonist Antibody

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Catalog #
100182
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Description

Recombinant monoclonal antibody recognizing human CD28.  This antibody binds to CD28 on T cells and promotes T cell response. 

Synonyms
T-Cell-Specific Surface Glycoprotein, TP44
Product Info
Storage and Usage
Citations
Species
Human
Isotype
IgG1
Clonality
Monoclonal
Host Species/Expression System
HEK293
Purity

≥90%

Purification
Protein A affinity chromatography from HEK293 supernatants.
Format
Aqueous buffer solution.
Formulation
8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol
MW
Heavy Chain: 51 kDa; Light Chain: 27 kDa
UniProt #
P10747
Background
The T cell-specific receptor CD28 is an important regulator of the immune system. The ligation of CD28 and its ligands CD80/CD86 on the APC provides a critical costimulatory signal alongside T cell receptor (TCR) for T cell activation. The costimulatory signal can also be delivered by the interaction between CD28 and its agonist antibody.
References
1. Takemura, S., et al., FEBS Letters, 2000; 476: 266-271.