HSP90β, His-tag Recombinant
Catalog #
50292
$395
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Description
Human Heat Shock Protein 90β also known as Heat Shock Protein 90 Beta Family Member Endoplasmin, and Tumor Rejection Antigen, GenBank Accession No. AY359878, a.a. 1-724 (full length) with C-terminal His-tag, expressed in an E. coli expression system. MW = 84 kDa.
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Synonyms
HSP90b, Heat Shock Protein 90b, HSP90beta, HSP90β
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥70%
Supplied As
Aqueous buffer solution.
Formulation
40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
MW
84 kDa
Amino Acids
1-724 (full length)
Genbank #
AY359878
UniProt #
P08238
Background
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with > 100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins. Inhibition of Hsp90beta function has been shown to play a role
in tumorigenesis and disease progression.
References
1. Milicevic Z et al., Int J Oncol. 2008 Jun;32(6):1169-78.
2. Chao C.C. et al., J Cell Biochem. 2008 Jul 1;104(4):1286-96.
2. Chao C.C. et al., J Cell Biochem. 2008 Jul 1;104(4):1286-96.