HER2, GST-Tag Recombinant

Catalog #

40230

$375 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human HER2, also known as ERBB2 (erb-b2 receptor tyrosine kinase 2), encompassing amino acids 679-1255(end). This construct contains an N-terminal GST-tag. The recombinant protein was affinity purified

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Synonyms

Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, HER2, MLN19, NEU, NGL, HER-2

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Specific Activity

Product Info

Storage and Usage

Citations

Species

Human

Construct

HER2 (GST-679-1255(end))

Host Species/Expression System

Sf9

Purity

≥80%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, and variable glutathione

89 kDa

Amino Acids

679-1255(end)

Specific Activity

≥40 pmole/min/µg

Genbank #

NM_004448

UniProt #

P04626

Tag(s)

N-terminal GST-tag

References

1. Meyer, M. et al., EMBO J. 18, 363-374 (1999).
2. Rahimi, N. et al., J. Biol Chem 275, 16986- 16992 (2000).

Application References:
1. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors (2021)

Storage/Stability

At least 6 months at –80°C

Assay Conditions

Assay was done according to HER2 Kinase Assay Kit (BPS Bioscience #40721) with various amounts of HER2.

Instructions for Use

Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.

Applications

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Shipping Temperature

-80°C

Warnings

Avoid freeze/thaw cycles

Scientific Category

Kinase/Receptor Tyrosine

Regulatory Status

Research Use Only

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Datasheets/Protocols

40230 Lot 220316-3

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HER2, GST-Tag Recombinant

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