ERK1 Recombinant

Catalog #

40055

$410 *

Size: 10 µg

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Synonyms

MAPK3, PRKM3, P44ERK1, P44MAPK, HS44 kDaP, HUMKER1A, MGC20180, ERK-1

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Specific Activity

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

44 kDa

Amino Acids

1-379(end)

Specific Activity

375 pmol/min/µg

Genbank #

NM_002746

UniProt #

P27361

Tag(s)

none

Background

ERK1 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines (1). Activation of ERK1 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK1 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK1 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta).

References

Boulton, TG. et al. Biochemistry. 1991 Jan 8,30(1):278-86.

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Datasheets/Protocols

40055 Lot 200130

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