Den1, GST-tag Recombinant

Catalog #
81084
$315 *
Size: 25 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Description

Human Den1 recombinant protein, with GST-tag, expressed in E. coli.

Synonyms
DEN1, Deneddylase-1, FKSG8, HsT17512, NEDD8-specific protease 1, NEDP1, Protease, cysteine 2, PRSC2, Sentrin/SUMO-specific protease SENP8, Sentrin-specific protease 8
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Format
Aqueous buffer solution
MW
51 kDa
UniProt #
Q96LD8
Tag(s)
GST-tag
Background
DEN1 (SENP8, NEDP1) is a deNEDDylase that deconjugates NEDD8 conjugates. A recent study demonstrated that DEN1 deNEDDylated the tumor suppressor breast cancer-associated protein BCA3. Full length DEN1 cleaves NEDD8-PLA2 with high efficiency.
References
1. Mendoza, H.M., et al., NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J. Biol. Chem., 2003. 278(28):25637?43.
2. Gan?Erdene, T., et al., Identification and characterization of DEN1, a deneddylase of the ULP family. J. Biol. Chem., 2003. 278(31):.28892?900.
3. Wu, K., et al., DEN1 Is a Dual Function Protease Capable of Processing the C-Terminus of Nedd8 and Deconjugating Hyper?neddylated CUL1. J. Biol. Chem., 2003. 278(31):28882?28891.