Cell Surface Receptor(s)

 

Cell surface receptors, often called transmembrane receptors, are important proteins that mediate communication between the cell and the outside world. Extracellular ligands (cytokines, growth factors, hormones, neurotransmitters, or cell recognition molecules) bind to the receptor, triggering conformational changes that initiate intracellular signaling pathways (signal transduction). Cell surface receptors regulate a multitude of biological pathways required for cell growth, differentiation, proliferation, and survival.

Because of the critical nature of these pathways, it is not surprising that mutations in cell surface receptors are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis. In fact, nearly half of all drugs in clinical use target cell surface receptors, and these proteins and their ligands remain extremely important targets for structure-based drug design and novel drug development.

Cell Surface Receptors are divided into 3 major classes: ion channel-linked receptors, enzyme-linked receptors, and G protein-coupled receptors.

Ion channels are pore-forming proteins present in the membranes of all cells. Ions pass through channels down their electrochemical gradient, without the requirement for ATP or metabolic energy. Ion channels are especially prominent components of the nervous system, since "transmitter-activated" channels mediate conduction across nerve synapses. Ion channels are also key components in the cellular response to toxins and venoms, as well as biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, T-cell activation and hormone release.

Enzyme-linked receptors are usually single-pass transmembrane receptors. This group includes the highly studied receptor tyrosine kinases (RTKs), which bind to polypeptide growth factors that control cell proliferation and differentiation. Also included are receptor serine/threonine kinases, receptor-like tyrosine phosphatases, and receptor guanylyl cyclases that catalyze the production of cyclic GMP in the cytosol.

G-protein-coupled receptors (GPCRs), also known as 7 transmembrane (7-TM) receptors, are structurally and functionally related proteins characterized by seven membrane-spanning a helices. GPCRs are involved in numerous signaling pathways, including sensory perception (sight, smell, taste, pain). GPCRs are also activated by many neurotransmitters, neuropeptides, and peptide hormones.

Our portfolio of cell surface receptor products includes antibodies, assay kits, cell lines for GPCRs and ion channels, and purified soluble receptors.

References:

1.  Overington, J.P., et al., Nat. Rev. Drug Disc. 2006; 5: 993-996.
2.  Sallman, M. et al., BMC Biol. 2009; 7: 50. 

 

Cell Surface Receptor Subcategories

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Catalog#SizeProduct NamePrice
71197 100 μg CD112, His-tag (Human) HiP™
$320
72510 100 μg CD113, Fc-Fusion (IgG1), Avi-Tag
$320
71170 100 µg CD137 (4-1BB), Fc fusion (Human) HiP™
$310
71171 50 µg CD137 (4-1BB), Fc Fusion, Biotin-labeled (Human) HiP™
$415
71250 100 μg CD137, Fc fusion (hIgG1) (Mouse)
$320
71254 100 µg CD137, Fc fusion (mIgG2a), Avi-tag (Mouse) HiP™
$320
71255 50 µg CD137, Fc fusion (mIgG2a), Biotin-labeled (Mouse) HiP™
$435
71189 100 µg CD137L (4-1BB ligand), His-tag
$320
72517 100 µg CD137L, His-Tag (Mouse)
$320
72025 96 reactions CD137[Biotinylated]:CD137L Inhibitor Screening Assay Kit
$1,025
72307 50 μg CD150, Fc Fusion (IgG1), Biotin Labeled (Human)
$435
72304 100 μg CD150, Fc Fusion, Avi-Tag (Human)
$330
71173 100 µg CD160, His-tag (Human) HiP™
$320
71135 50 µg CD160, His-tag, Biotin-labeled (Human) HiP™
$435
79472 100 μg CD19, Fc-Fusion (IgG1), Avi-Tag
$320
79475 50 μg CD19, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled
$435
71264 100 μg CD2, Fc fusion, Avi-Tag, (Human) HiP™
$330
71270 50 µg CD2, Fc fusion, Biotin-labeled (Human) HiP™
$435
79464 100 μg CD22, Fc-fusion, Avi-Tag HiP™
$325
79466 50 μg CD22, Fc-fusion, Avi-Tag, Biotin-labeled HiP™
$435
71252 100 µg CD226, Fc fusion (Human) HiP™
$320
71253 50 µg CD226, Fc fusion, Biotin-labeled (Human) HiP™
$435
72051 384 reactions CD226:CD112 Homogeneous Assay Kit
$335
72052 384 reactions CD226:CD155 Homogeneous Assay Kit
$335
72305 100 μg CD244, Fc Fusion (IgG1), Avi-Tag (Human)
$330

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