Autoimmunity Research Products

Developing targeted therapies for autoimmunity and its wide array of diseases is an emerging research area for immunotherapy and adoptive cell therapy.

Developing targeted therapies for autoimmunity and its wide array of diseases is an emerging research area for immunotherapy and adoptive cell therapy.

Autoimmunity occurs when the immune system attacks the body's own tissues, mistaking them for foreign invaders. An imbalance in immune tolerance leads B cells and T cells to self react, resulting in a range of autoimmune diseases, such as rheumatoid arthritis (RA), lupus, inflammatory bowel disease (IBD) and multiple sclerosis (MS), each affecting different organs and systems. While the exact causes are not fully understood, it is believed to involve a combination of genetic predisposition and environmental factors, such as infections or exposure to certain chemicals. The immune system's inability to distinguish between self and non-self antigens leads to chronic inflammation and tissue damage, significantly impacting the quality of life for those affected.

Emerging therapies for autoimmunity aim to target the underlying mechanisms of these diseases rather than just alleviating symptoms. Biological therapies, such as monoclonal antibodies, have been at the forefront of this approach. For example, tumor necrosis factor alpha (TNF-α) inhibitors like infliximab and adalimumab have shown effectiveness in treating rheumatoid arthritis and other autoimmune conditions by blocking TNF-α, a proinflammatory cytokine. Targeting of other cytokines such as TL1A are now in development for IBD and ulcerative colitis. Additionally, therapies targeting specific immune cells, such as B cells and T cells, are being developed. Rituximab, an anti-CD20 antibody, depletes B cells and is used in conditions like multiple sclerosis and lupus, while targeting immune checkpoints to promote T cell tolerance is also under investigation.

Essential tools for autoimmunity therapeutic discovery

Cell Lines & Primary Cells

• Reporter cells for co-culture assays to screen for inhibitors
• Immune checkpoint molecule or ligand-expressing cell lines
• TCR and B2M knockout cells
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Antibodies & Multi-specific Molecules

• Find conventional antibodies against autoimmune targets, immune cell markers, multi-specific antibodies, and T cell engagers for your research.
• Neutralizing and flow cytometry Abs
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Assay Kits

• Biochemical and cell-based assay kits to screen for inhibitors
• High throughput options available, including homogeneous assays in 384-well plates
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Purified Recombinant Proteins

• With or without tags, including Avi-Tag™, FLAG, His, Fc or biotin for binding assays or WB controls.
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Custom Product Development

Looking for custom products for your research project? We can help with that. Contact us or view our custom development options.

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