Anti-CD20 Functional Antibody

Catalog #
71209
$325 *
Size: 100 µg
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Description

Anti-CD20 Functional Antibody is a chimeric monoclonal antibody that recognizes human CD20. The antibody features the constant region of the human IgG1 isotype and the mouse variable region of rituximab (amino acids 142-184). This antibody is cytotoxic to WIL2-S cells in the presence of the rabbit complement system.  The recombinant antibody was affinity purified.

Synonyms
rituximab
Product Info
Storage and Usage
Citations
Species
Human
Isotype
IgG1
Clonality
Monoclonal
Host Species/Expression System
Mouse/Human/HEK293
Purity

≥90%

Format
Aqueous buffer solution
Formulation

8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

MW
Heavy Chain: 51 kDa; Light Chain: 25 kDa
UniProt #
P11836
Background

CD20 is present in the membrane of mature, normal, and abnormal B cells, but not in immature B cells. This expression pattern made it an attractive target for antibody-based lymphoma treatment as immature B cells will not be affected and can replenish the B cell population. Rituximab was the first anti-CD20 monoclonal antibody to reach the clinic, and since its commercialization it has led to a decrease in the number of deaths due to B cell malignancy. 

References

1. Ganjoo KN, et al., Leuk Lymphoma. 2014 April 9.

2. Siegal T., J Clin Neurosci. 2014 April;21(5):709-715.