ALK1 (ACVRL1), GST-tag Recombinant
Catalog #
40018
$410
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Description
Recombinant human activin receptor-like kinase 1, or ALK1, (a.a. 144-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_000020.
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Synonyms
ACVRL1, ACVRLK1, ALK1, HHT, HHT2, ORW2, SKR3, ALK1, TSR-I
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥78%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl pH 8.0,
110 mM NaCl, 2.2 mM KCl, 0.04% Tween20,
0.2mM EDTA, 3mM DTT and 20%
glycerol.
MW
64 kDa
Amino Acids
144–end
Specific Activity
13 pmol/min/µg
Genbank #
NM_000020
UniProt #
P37023
Background
ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFβ superfamily (1). ALK1 functions as a TGFβ type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFβ signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported (2).
References
1. Ota, T. et al . J. Cell Physiol. 2002;193(3):299-318.
2. Tsuzuki, T. et al. Am. J. Surg. Pathol. 2004; 28(12):1609-14.
2. Tsuzuki, T. et al. Am. J. Surg. Pathol. 2004; 28(12):1609-14.