ABL2, His-tag Recombinant

Catalog #

40417

$410 *

Size: 10 µg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Recombinant human ABL2 (a.a. 38-end), with N-terminal His-tag, expressed in Sf9 insect cells via a baculovirus expression system.

●

Synonyms

ARG, abll, Abelson murine leukemia, ABL-2

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM sodium phosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol

132 kDa

Amino Acids

38–end

Genbank #

NM_005158

UniProt #

P42684

Tag(s)

N-terminal His-tag

Background

ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas (1). Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments (2).

References

1. Barila, D. et al : An intramolecular SH3-domain interaction regulates c-Abl activity. Nature Genet. 18: 280-282, 1998.
2. Griesinger, F. et al: Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line. Br J Haematol. 2002 Nov;119(2):454-8.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

ABL2, His-tag Recombinant

PRODUCTS

SERVICES

RESOURCES

COMPANY