Human Lymphotactin(XCL1) Recombinant
Catalog #
90210-B
$205
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Description
Recombinant Lymphotactin is a disulfide-linked homodimeric protein consisting of 93 amino acid residues, and migrates as an approximately 10 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human lymphotactin (XCL1) mature chain was expressed in E. coli.
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Synonyms
XCL1, lymphotactin, C Motif Chemokine 1, lymphotaxin, SCM-1a, ATAC, LPTN, LTN
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥97% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered PBS solution, pH 7.0.
MW
10 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
23–114
Biological Activity
Activity was determined by the ability to induce chemotaxis of human T-cells at concentrations ranging between 50-100 ng/ml.
Genbank #
P47992
UniProt #
P47992
Background
XCL1, also known as lymphotactin or ATAC, is the sole member of the C subgroup of chemokines, and is produced mainly by activated CD8 T cells (and to a lesser extent by NK and mast cells). The chemotactic activity of XCL1 is restricted to lymphocytes and has no effect on monocytes.
References
1. Hedrick JA, Zlotnik A. Clin Immunol Immunopathol. 1998 Jun,87(3):218-22.
2. Volkman BF, et al. Methods Enzymol. 2009, 461:51-70.
2. Volkman BF, et al. Methods Enzymol. 2009, 461:51-70.
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