14-3-3 zeta Protein, His-tag (Mouse) Recombinant
Catalog #
79040
$395
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Description
Mouse 14-3-3 zeta Protein, GenBank Accession No. NM_011740, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 31 kDa.
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Synonyms
Ywhaz; 1110013I11Rik; 14-3-3zeta; AI596267
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Mouse
Host Species/Expression System
Sf9 insect cells using baculovirus
Formulation
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol
MW
31 kDa
Amino Acids
Full length
Genbank #
NM_011740
Background
14-3-3 zeta (also known as tyrosine 3-monooxygenase /tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 zeta protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3 zeta protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2).
References
1. Li, Z. et al: Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci U S A. 2008; 105(1):162-7.
2. Niemantsverdriet, M. et al: Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character. Oncogene. 2008;27(9):1315-9. 2007.
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