Zaprinast

Catalog #

27218

$110 *

Size: 10 mg

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

Zaprinast is a cGMP-specific PDE inhibitor which moderately inhibits PDE5 and PDE6. It weakly inhibits PDE9, PDE10 and PDE11. Sildenafil (Viagra™) was developed from Zaprinast, which enhances the vasodilatory effects of nitric oxide in a range of vascular tissues by prolonging the cGMP-mediated activation of cGMP-dependent protein kinase. Also, GPR35 is activated by Zaprinast.

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Format

A crystalline solid.

Formula

C₁₃H₁₃N₅O₂

271.3 Da

Solubility

Soluble in DMSO and DMF, purged with an inert gas. Solubility in DMSO and DMF is ~10 mg/ml. For maximum solubility, dissolve in DMF and then dilute with the aqueous buffer of choice.

Biological Activity

Zaprinast inhibits PDE5 and PDE6 with IC50 values of 0.5-0.76 µM and 0.15 µM, respectively.

CAS Registry #

37762-06-4

References

1. Nakamizo, T., et al., J. Neurosci. Res. 2003;71:485-495.
2. Gibson, A., et al., Eur. J. Pharmacol. 2001;411:1-10.
3. Taniguchi, Y., et al., FEBS Lett. 2006;580:5003-5008.

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