Z-VAD-FMK, Methyl Ester
Catalog #
27017
$165
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Description
Z-VAD(OMe)-FMK is a cell permeable, irreversible pan-caspase inhibitor and anti-apoptotic agent. It has been shown to inhibit Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). Inhibits caspases 1, 3, 4, and 7.
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Synonyms
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone, Z-VAD(OMe)-FMK, Z-Val-Ala-Asp(OMe)-FMK, Z-Val-Ala-Asp-FMK, Methyl Ester
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥99%
Format
A white or off-white solid
Formula
C22H30FN3O7
MW
467.5 Da
Solubility
DMSO (>10 mg/ml), dimethyl formamide (7 mg/ml) or 100% ethanol (1.3 mg/ml)
CAS Registry #
187389-52-2
References
Rodríguez-Enfedaque, A., et al. Biochim. Biophys. Acta. 1823: 1343-1352 (2012).
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