XAV939

Catalog #

27100

$190 *

Size: 10 mg

Qty

Bulk/Custom

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Description

XAV 939 is a small molecule and selective Wnt pathway transcription factor - catenin-mediated transcription inhibitor and axin stabilizing agent. It stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex and stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2).

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Product Info

Storage and Usage

Citations

Purity

≥99% by HPLC

Format

White to beige powder.

Formula

C₁₄H₁₁F₃N₂OS

312.3 Da

Solubility

Soluble in DMSO at 25 mg/ml.

Biological Activity

XAV939 inhibited TNKS1 and TNKS2 with IC50 of 4.6 nM and 1.68 nM, respectively using BPS Bioscience TNKS1 Assay Kit (Cat. # 80564) and TNKS2 Assay Kit (Cat. # 80566).

CAS Registry #

284028-89-3

References

Huang, SM. et al. Nature. 2009 Oct 1; 461(7264):614-20.

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