WDR5, His-tag Recombinant
Catalog #
71200
$460
*
●
●
Purchase
Description
Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
●
Synonyms
WDR5, WD Repeat Domain 5, SWD3, BIG-3, Set1c WD40 Repeat Protein, BMP2-Induced 3-Kb Gene Protein, WDR-5
●
Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
MW
37.5 kDa
Amino Acids
2–334(end)
Genbank #
NM_017588
UniProt #
P61964
Background
As part of the MLL1/MLL complex, WDR5 is involved in methylation and dimethylation at Lys4 of histone H3, which is a specific tag for epigenetic transcriptional activation. As part of the NSL complex, it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. WDR5 may regulate osteoblasts differentiation. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes WDR5 contains 7 WD repeats.
References
1. Trievel, R.C., Shilatifard, A. (2009). Nature Struct. Mol. Biol. 16 (7): 678-80.
2. Wang, Y.Y., et al. (2010). Proc. Natl. Acad. Sci. USA 107(2):815-20.
3. Odho, Z., et al. (2010). J. Biol. Chem. 285(43):32967-76
2. Wang, Y.Y., et al. (2010). Proc. Natl. Acad. Sci. USA 107(2):815-20.
3. Odho, Z., et al. (2010). J. Biol. Chem. 285(43):32967-76
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.