Vismodegib (GDC-04491)
Catalog #
27010
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Description
Vismodegib (GDC-0449) is a potent hedgehog (Hh) signaling pathway inhibitor.
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Product Info
Storage and Usage
Citations
Purity
≥99% by HPLC
Format
A crystalline solid.
Formula
C19H14Cl2N2O3S
MW
421.3 Da
Solubility
Soluble in DMSO at 200 mg/ml; soluble in ethanol at 10 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM
Biological Activity
Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, with IC50 values of 1.4 and 3.0 µM, respectively.
CAS Registry #
879085-55-9
References
1. Von Hoff, D.D., et al. N. Engl. J. Med. 361: 1164-1172 (2009).
2. Zhang, Y., et al. Neoplasia 11: 96-101 (2009).
2. Zhang, Y., et al. Neoplasia 11: 96-101 (2009).
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