Valproic Acid

Catalog #

27207

$165 *

Size: 10 g

Qty

Bulk/Custom

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Description

Valproic acid inhibits histone deacetylases (HDACs), in particular Class I HDACs. It is an analog of the natural fatty acid valeric acid. Valproic acid also inhibits GSK3 and depletes cellular inositol-1,4,5-triphosphate. It can have strong effects on stem cell differentiation and self-renewal, and it shows promise in treating cancer and Alzheimer’s disease.

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC

Format

A crystalline solid.

Formula

C₈H₁₆O₂ Na

167.2 Da

Solubility

Soluble in ethanol, DMSO and dimethyl formamide (DMF). Solubility in ethanol is 30 mg/ml and 5 mg/ml in DMSO and DMF. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.

Biological Activity

Valproic acid inhibits Class I HDACs with an IC50 of ~ 2 mM.

CAS Registry #

1069-66-5

References

1. Jung, G., et al., BMC Cell Biol. 2008; 9(66).
2. Bug, G., et al., Cancer Res. 2005; 65(7): 2537 – 2541.
3. Gottlicher, M., et al., EMBO J. 2001; 20(24): 6969 – 6978.

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Valproic Acid

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