UTX (KDM6A), C-term FLAG-tag

Catalog #: 50116
Size: 20 µg
$435
Species: Human
Host Species: Sf9 insect cells
MW: 155 kDa
Genbank #: NM_021140
Tag(s): C-terminal FLAG-tag
a.a: 1–1401
Description:
Human UTX, also known as KDM6A (GenBank Accession No. NM_021140) (a.a. 1-1401) with C-terminal FLAG-tag, MW = 155 kDa, expressed in Sf9 cells via a baculovirus expression system.
UniProt
O15550
Synonym(s):
KDM6A
Formulation:
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 80 µg/ml FLAG peptide
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at –80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):

1. Greenfield, A., et al., (1998). Hum. Mol. Genet. 7(4):737–42.
2. Agger, K., et al., (2007). Nature. 449(7163):731–4.1. Suzuki, T., et al., (2013). J Med Chem. 56(18):7222-31. 

Application Reference(s):
1. Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction (2017)
2. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity (2013)

Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Demethylase
Product Type:
Recombinant Protein
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Product Datasheets

50116_Lot130220.pdf