USP33 Core Domain, SUMO-His-tags Recombinant
Catalog #
81102
$425
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Description
Human USP33 Core Domain recombinant protein (Genbank Accession No. Q8TEY7), a.a. 181–712, with N-terminal SUMO- and His-tags, expressed in E. coli.
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Synonyms
VHL-interacting deubiquitinating enzyme, Deubiquitinating enzyme 33, KIAA1097, MGC16868, Ubiquitin carboxyl-terminal hydrolase 33, Ubiquitin-specific-processing protease 33, Ubiquitin thioesterase 33, VDU1, USP 33, USP-33
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM DTT, 10% glycerol
MW
61 kDa
Amino Acids
181–712
Genbank #
Q8TEY7
UniProt #
Q8TEY7
Background
USP33 was originally identified as a protein that interacts with the E3 ubiquitin ligase pVHL, a region commonly mutated in patients with pVHL disease and has been shown to be ubiquitylated by the pVHL E3 ligase complex in vitro and in transiently transfected COS-7 cells. The USP33 catalytic core spans amino acids 181-712.
References
1. De Pitta, C., et al. A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. Haematologica 90(7): p. 890-8 (2005).
2. Li, Z., et al., Ubiquitination of a novel deubiquitinati ng enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 277(7): p. 4656-4662 (2002).
2. Li, Z., et al., Ubiquitination of a novel deubiquitinati ng enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 277(7): p. 4656-4662 (2002).
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