UPF 1069
Catalog #
27665-1
$155
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Description
UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.
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Synonyms
5-phenacyloxy-2H-isoquinolin-1-one
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Target(s)
PARP2
Formula
C17H13NO3
MW
279.3 Da
Solubility
Soluble in DMSO
Biological Activity
UPF 1069 is a selective inhibitor of PARP2 with IC50 of 0.3 µM. It is ~27-fold selective for PARP2 vs. PARP1 (IC50 = 8 µM).
CAS Registry #
1048371-03-4
References
Moroni F, et al. Br J Pharmacol. 2009;157(5):854-862
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