Ubiquitination

Ubiquitin is an 8.5 kDa protein that is expressed in almost all tissues, hence the name. Ubiquitination is a post-translational modification in which one or more ubiquitin proteins is added to a substrate protein by a reaction that is carried out in three main steps; activation, conjugation, and ligation. Addition requires the sequential action of 3 enzymes, ubiquitin activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome, but was later found to have a number of distinct functions such as altered protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteosomal degradation pathway, ubiquitin modifications have been linked to the regulation of a number of other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target.

BPS provides a number of active ubiquitin enzymes in addition to inhibitors and activators to give researchers the tools necessary to continue to advance our understanding of this important target.

Items 76 to 100 of 113 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Catalog#SizeProduct NamePrice
80323 100 µg UbcH13 (UBE2N), His-tag
$245
80315 100 µg UbcH5a (UBE2D1), His-tag
$245
80314 100 µg UbcH5b, His-Tag (Human)
$245
80313 100 µg UbcH5c, His-Tag (Human)
$245
80316 100 µg UbcH6 (UBE2E1), His-tag
$245
80317 100 µg UbcH7, His-tag (E. coli-derived)
$280
80318 50 µg UbcH7, His-tag (Sf9-derived)
$280
80301 100 µg UBE1 (UBA1), FLAG-tag
$295
79368 20 µg UBE2A, His-Tag
$280
79369 20 µg UBE2C, His-Tag
$280
79370 20 µg UBE2D2, His-Tag
$280
80302 20 µg UBE3A, His-FLAG-tags
$360
81150 50 µg Ubiquitin AMC
$340
79293 2 mg Ubiquitin, His-Tag
$95
81151 50 µg Ubiquitin-Rhodamine
$360
81099 25 µg UCH-L5, SUMO-His-tags
$400
80351 100 µg UCHL1 (PGP9.5), His-tag
$355
80353 100 µg UCHL3, His-tag
$355
80325 100 µg UEV1A (UBE2V1), FLAG-tag
$280
80411 20 µg UFL1, GST-tag
$360
55001 50 µg UHRF1, His-FLAG-tags
$425
80360 50 µg USP10, FLAG-tag
$415
80364 50 µg USP14, FLAG-tag
$415
81100 25 µg USP15, SUMO-His-tags
$340
80352 50 µg USP2, FLAG-tag (Sf9-derived)
$425

Items 76 to 100 of 113 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5