Ubiquitination

Ubiquitin is an 8.5 kDa protein that is expressed in almost all tissues, hence the name. Ubiquitination is a post-translational modification in which one or more ubiquitin proteins is added to a substrate protein by a reaction that is carried out in three main steps; activation, conjugation, and ligation. Addition requires the sequential action of 3 enzymes, ubiquitin activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome, but was later found to have a number of distinct functions such as altered protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteosomal degradation pathway, ubiquitin modifications have been linked to the regulation of a number of other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target.

BPS provides a number of active ubiquitin enzymes in addition to inhibitors and activators to give researchers the tools necessary to continue to advance our understanding of this important target.

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Catalog#SizeProduct NamePrice
81090 25 µg PLP2, His-tag
$360
81091 25 µg PLPro, His-tag
$360
27714-1 5 mg PR-619
$210
27714-2 5x5 mg PR-619 (5X5MG)
$675
81055 25 µg Praja1, SUMO-tag
$370
27715-2 5 mg PS-341 (MG-341)
$235
27715-1 25 mg PS-341 (MG-341)
$820
27716-2 25 mg PYR-41
$215
27716-1 10 mg PYR-41
$140
80406 20 µg RNF20, His-FLAG-tags
$360
81092 25 µg SENP1 Core Domain, His-tag
$260
81095 5000 units SENP2, His-tag
$2,975
81096 500 units SENP2, His-tag
$400
81097 25 µg SENP6 Core Domain, His-tag
$360
27717 50 mg SL-01
$110
27718-1 10 mg SMER3
$105
27718-2 50 mg SMER3
$330
80402 20 µg SMURF1, FLAG-tag
$360
80403 20 µg SMURF2, FLAG-tag
$360
81098 25 µg Ssel, His-tag
$360
27719 100 mg TAME-HCL
$75
27720-1 10 mg TCID
$105
27720-2 50 mg TCID
$330
27721-1 200 mg Thalidomide
$130
80303 100 µg UBA6 (UBE1L2), FLAG-tag
$280

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