Ubiquitination

Ubiquitin is an 8.5 kDa protein that is expressed in almost all tissues, hence the name. Ubiquitination is a post-translational modification in which one or more ubiquitin proteins is added to a substrate protein by a reaction that is carried out in three main steps; activation, conjugation, and ligation. Addition requires the sequential action of 3 enzymes, ubiquitin activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome, but was later found to have a number of distinct functions such as altered protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteosomal degradation pathway, ubiquitin modifications have been linked to the regulation of a number of other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target.

BPS provides a number of active ubiquitin enzymes in addition to inhibitors and activators to give researchers the tools necessary to continue to advance our understanding of this important target.

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Catalog#SizeProduct NamePrice
81085 25 µg JosD1, His-tag
$400
81086 25 µg JosD2, His-tag
$400
80410 20 µg KCTD13, GST-tag
$360
27705 500 ug Lactacystin
$340
27706-2 50 mg LDN-57444
$430
27706-1 10 mg LDN-57444
$170
27707 25 mg MDBN
$245
80751 20 µg MDM2, GST-tag
$365
27708 1 mg MLN-4924
$295
81052 25 µg MuRF1, SUMO-His-tags
$345
81053 25 µg MuRF2, SUMO-tag
$345
81054 25 µg MuRF3, SUMO-His-tags
$345
80404 20 µg NEDD4, FLAG-tag
$375
81087 50 µg NEDD8 E1, His-tag
$285
27709-1 10 mg NSC-632839
$175
27709-2 50 mg NSC-632839
$300
27710 10 mg NSC-66811
$225
27765-1 10 mg NSC697923
$135
27765-2 25 mg NSC697923
$175
81088 25 µg Otub1, His-tag
$305
81089 25 µg Otub2, His-tag
$340
80407 50 µg OTUD6B, His-FLAG-tags
$415
27767-2 50 mg P005091
$320
27767-1 10 mg P005091
$140
27712-1 10 mg P22077
$230

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