IU1

Catalog #

27227

$145 *

Size: 10 mg

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Description

IU1 is a small molecule, reversible inhibitor of deubiquitination by USP14. It selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 µM and in MEF cells at 50 µM. IU1 can also reduce accumulation of oxidized proteins in HEK293 cells, which alleviates cytotoxicity induced by oxidative stress.

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Synonyms

1–[1–(4–Fluorophenyl)–2,5–dimethyl–1H–pyrrol–3–yl]–2–(1–pyrrolidinyl)ethanone, USP-14

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Format

A crystalline solid.

Formula

C₁₈H₂₁FN₂O

300.4 Da

Solubility

Soluble in DMSO, DMF and ethanol purged with an inert gas. Solubility is approximately 20 mg/ml in DMSO, DMF and ethanol. For maximum solubility, dissolve in DMF, then dilute with aqueous buffer of choice.

Biological Activity

IU1 inhibits deubiquitination by USP14, demonstrating an IC50 value of 4-5 µM.

CAS Registry #

314245-33-5

References

1. Lee et al (2010). Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467:179. PMID: 20829789.
2. Lee et al. (2010). Trimming of ubiquitin chains by proteasome -associated deubiquitinating enzymes. Mol. Cell. Proteomics 10:R110.

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