DBeQ

Catalog #
27703-1
$200 *
Size: 10 mg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
Purchase
Description

DBeQ is cell permeable, potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks both ubiquitin dependent and endoplasmic reticulum-associated degradation pathways, protein clearance pathways, and activates caspases -3 and -7 inducing apoptosis.

Synonyms
JRF 12; DBeQ; N2,N4–Dibenzylquinazoline–2,4–diamine
Product Info
Storage and Usage
Citations
Purity
>98% by TLC.
Format
Yellow powder
Formula
C22H20N4
MW
340.4 Da
Solubility
Soluble in DMSO (25 mg/ml)
CAS Registry #
177355-84-9
References
1. Chou TF, et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl. Acad. Sci. USA. 2011. Mar 22; 108:4834-9.