Celastrol

Catalog #: 27702-1
Size: 10 mg
$235
MW: 450.6 Da
CAS Registry #: 34157-83-0
Formula: C29H38O4
Description:
Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM). Cell permeable.
Synonym(s):
Tripterine
Purity:
>98% by TLC.
Solubility:
Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml)
Format:
Red powder
Storage / Stability:

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.

Application(s):
Useful for inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity.
Reference(s):
1. Sethi, G., et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood, 2007, 109:2727.
2. Westerheide, S.D. et al. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 2004. 279:56053.
3. Kiaei, M., et al. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2005, 2:246.
Warning(s):
Protect from light. Protect from moisture. Avoid freeze/thaw cycles.
Scientific Category:
Ubiquitin Enzymes
Product Type:
Inhibitors/Activators
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