Celastrol

Catalog #
27702-1
$240 *
Size: 10 mg
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Description

Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM). Cell permeable.

This product has been cited 1 time.

Synonyms
Tripterine
Product Info
Storage and Usage
Citations1
Purity
>98% by TLC.
Format
Red powder
Formula
C29H38O4
MW
450.6 Da
Solubility
Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml)
CAS Registry #
34157-83-0
References
1. Sethi, G., et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood, 2007, 109:2727.
2. Westerheide, S.D. et al. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 2004. 279:56053.
3. Kiaei, M., et al. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2005, 2:246.