UBE2C, His-Tag Recombinant

Catalog #
79369
$325 *
Size: 20 µg
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Description

Recombinant human UBE2C (ubiquitin-conjugating enzyme E2 C), full length. This construct contains an N-terminal His-tag. This protein was affinity purified.

Synonyms
dJ447F3.2, UBCH10
Product Info
Storage and Usage
Citations
Species
Human
Construct
UBE2C (His-Full Length)
Host Species/Expression System
E. coli
Purity

≥90%

Format

Aqueous buffer solution

Formulation

50 mM Sodium Phosphate, pH 7.0, 300 mM NaCl, 150 mM Imidazole, 0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol

MW
21 kDa
Specific Activity

16 pmol/min/µg

Genbank #
NM_007019
UniProt #
O00762
Tag(s)
N-Terminal His-Tag
Background
UBE2C or ubiquitin-conjugating enzyme E2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C acted as a dominant-negative inhibitor which blocks the destruction of mitotic cyclins A and B and the onset of anaphase in frog embryos and mammalian cells. High UBE2C mRNA expression is associated with poor disease-free survival and overall survival. High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C.
References

1. Mondal, S., et al., Anal. Biochem. 2016; 510: 41-51.

2. Rape, M., et al., Nature. 2004; 432: 588-595.