U0126

Catalog #: 27012
Size: 25 mg
$245
MW: 380.5 Da
CAS Registry #: 109511-58-2
Formula: C18H16N6S2
Description:
U0126 is a selective inhibitor of mitogen-activated protein kinase kinases, MEK-1 and MEK-2. It is a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.
Purity:

≥99% by HPLC

Biological Activity:
U0126 antagonizes AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 0.07 µM for MEK1 and 0.06 µM for MEK2.
Solubility:
Soluble in DMSO at 200 mg/ml. It is poorly soluble in ethanol and water.
Format:
White to off-white crystalline solid; granular or powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):

1. Favata, M.R., et al., J. Biol. Chem. 1998; 273: 18623 – 18632.
2. DeSilva, D.R., et al., J. Immunol. 1998; 160: 4175 – 4181.
3. Scherle, P.A., et al., J. Immunol. 1998; 161: 5681 – 5686.

Application Reference(s):
1. Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition (2017)

Scientific Category:
Kinase
Product Type:
Inhibitor
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Product Datasheets

27012_Lot120316.pdf