Tyrphostin AG 1478

Catalog #: 27035
Size: 25 mg
MW: 315.8 Da
CAS Registry #: 175178-82-2
Formula: C16H14ClN3O2
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Much weaker inhibitor of PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner.
AG 1478



Soluble in DMSO at 50 mg/ml; soluble in ethanol at 25 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. 

A white solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
1. Osherov, N. and Levitzki, A. Eur. J. Biochem. 225: 1047-1053 (1994).
2. Levitzki, A. and Gazit, A. Science 267: 1782-1788 (1995).
3. Choi, B.H., et al. Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
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