TRPC7-HEK293 Recombinant Cell Line
Catalog #
90030
$9,400
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Purchase
Description
Stable, recombinant HEK293 cell line expressing human TRPC7 (transient receptor potential cation channel, subfamily C, member 7, accession number NM_020389).
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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Synonyms
TRPC7, transient receptor potential cation channel, subfamily C, member 7
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Product Data Gallery
Methacholine-activated Ca2+ entry in TRPC7 expressed HEK293 cells
A) TRPC7-HEK293 cells; B) WT-HEK293 cells
Product Info
Storage and Usage
Citations
Host Cell Line
HEK293 cells
Species
Human
Supplied As
Each vial contains ~1.5 X 106 cells in 1 ml of 10% DMSO.
Biological Activity
N-terminal FLAG tagged human TRPC7 channel has been stably expressed in HEK293 cell line and its expression was confirmed by Western blotting. The function of TRPC7 was characterized by calcium assay. In TRPC7-HEK293 cells, addition of methacholine, an activator of phospholipase C-linked muscarinic receptors, significantly activates TRPC7, resulting Ca2+ entry in the cells.
Genbank #
NM_020389
UniProt #
Q9HCX4
Mycoplasma Testing
The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma Aldrich) to confirm the absence of Mycoplasma species.
References
1. Moran MM et al. (2011). Nat Rev Drug Discov. 10(8):601-620
2. Vassort G. and Alvarez J. (2009). Can. J. Physiol. Pharmacol. 87: 100-107
3. Lievremont J., et al. (2004). Am J Physiol Cell Physiol 287: C1709-C1716.
2. Vassort G. and Alvarez J. (2009). Can. J. Physiol. Pharmacol. 87: 100-107
3. Lievremont J., et al. (2004). Am J Physiol Cell Physiol 287: C1709-C1716.
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