Tenovin-6

Catalog #

27661-1

$195 *

Size: 1 mg

Qty

Bulk/Custom

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Description

Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as an activator of the p53 pathway. Studies show that Tenovin-6 increases p53 levels more than Tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.

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Synonyms

4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Target(s)

SIRTs 1-3

Formula

C₂₅H₃₄N₄O₂S

454.6 Da

Solubility

Soluble in DMSO

Biological Activity

Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 µM, 10 µM, and 67 µM, respectively.

CAS Registry #

1011557-82-6

References

McCarthy, A.R, et al. Bioorg Med Chem. 2012 Mar 1;20(5):1779-93.

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Tenovin-6

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