TCR Activator CHO Recombinant Cell line
Recombinant CHO cell line stably expressing an engineered, membrane-bound T cell receptor (TCR) activator. The cell line has been functionally validated in a co-culture assay for activation of the NFAT Reporter Jurkat cells and was shown to induce the proliferation of human Peripheral Blood Mononuclear Cells (PBMC).
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Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
| Name | Ordering Information |
| Thaw Medium 3 | BPS Bioscience #60186 |
| Growth Medium 3B | BPS Bioscience #79529 |
The cell line has been screened to confirm the absence of Mycoplasma species.
The T Cell Receptor (TCR) is a heterodimer protein found at the surface of T cells, which is stimulated upon binding to MHC/peptide complexes and triggers a signaling cascade that leads to the activation of transcription factors involved in the upregulation and secretion of cytokines, T cell proliferation, and cell differentiation into effector and memory cells.
When co-cultured with T cells, the engineered TCR activator cells stimulate the TCR on T cells, leading to activation of downstream signaling pathways and biological responses such as proliferation.
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