Staurosporine

Catalog #

27002

$125 *

Size: 1 mg

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Description

Staurosporine is a potent inhibitor of many kinases including protein kinase C, protein kinase A, and protein kinase G. It also induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons.

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC.

Format

Light yellow crystalline solid or solid film at bottom of vial.

Formula

C₂₈H₂₆N₄O₃

466.5 Da

Solubility

Soluble in DMSO or ethanol; insoluble in water.

Biological Activity

Staurosporine, a microbial alkaloid with antifungal activity, has been shown to inhibit a variety of kinases including PKA (Ki=7.0 nM), PKG (Ki=8.5 nM), MLCK (Ki=1.3 nM), PKC (Ki=0.7 nM), CaMK (IC50=20 nM), CAMKII (Ki=20nM), tyrosine kinases (IC50=70 nM) and phosphorylase kinase (IC50=0.5 nM).

CAS Registry #

62996-74-1

References

1. Matsumoto, H., et al. Biochem. Biophys. Res. Commun. 128: 105-109 (1989)
2. Tamaoki, T., et al. Biochem. Biophys. Res. Commun. 135: 397-402 (1986)
3. Boix, J., et al. Neuropharmacology 36: 811-821 (1997)

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