SMYD2 (KMT3C), FLAG-Tag Recombinant
Recombinant human SMYD2 (SET And MYND Domain Containing protein 2), encompassing amino acids 2-433(end). This construct contains an N-terminal FLAG-tag. This protein was affinity purified.
≥90%
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 0.2 mM TCEP, and 80 µg/ml FLAG peptide
0.004 pmole/min/µg
SMYD2 (SET (su(Var)3-9, Enhancer-of-zeste and Trithorax) And MYND (myeloid, Nervy and DEAF-1) Domain Containing protein 2), also known as KMT3C, is a member of the histone methyltransferase family of proteins, with lysine-specific activity. In addition to its role in histone H3K4 methylation, SMYD2 can also act on non-histone targets, such as p53 and PARP1 (poly-ADP ribose polymerase 1). SMYD2 is found at high levels in many cancer types and has been classified as an oncogene. It regulates cell proliferation and apoptosis, making it a promising cancer therapy target. The use of inhibitors or small interfering RNA can lead to decreased cell cancer viability as SMYD2 is critical for inhibition of TNF (tumor necrosis factor)-induced apoptosis. Targeting SMYD2 alone, or in combination with other therapies, may prove crucial in oncology.
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