Sirtinol

Catalog #

27652-1

$130 *

Size: 5 mg

Qty

Bulk/Custom

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Description

Cell-permeable, selective sirtuin inhibitor that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

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Synonyms

2-[[(Z)-(2-oxonaphthalen-1-ylidene)methyl]amino]-N-(1-phenylethyl)benzamide

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Target(s)

SIRT1, SIRT2

Formula

C₂₆H₂₂N₂O₂

394.5 Da

Solubility

DMSO 23 mg/ml, Water <1 mg/ml, Ethanol <1 mg/ml

CAS Registry #

410536-97-9

Background

Unlike TSA, Sirtinol does not inhibit class I and class II HDACs, indicating that it is a selective sirtuin inhibitor. The downregulation of SIRT1/2 expression plays an important role in the regulation of breast cancer apoptosis; thus, SIRT1/2 may be a novel molecular target for cancer therapy.

References

1. Wang J,et al. Int J Oncol. 2012 Sep;41(3):1101-9.
2. Grozinger CM, et al. J Biol Chem. 2001 Oct 19;276(42):38837-43.

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