SIRP-α (CD172a), His-tag (Human) Recombinant

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Catalog #

71145

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Description

Signal regulatory protein-alpha (SIRP-α), also known as Tyrosine-protein phosphatase non-receptor type substrate 1, CD172a, Bit, and MyD-1, GenBank Accession No. NM_080792, a.a. 27-370, with C-terminal His-tag, MW 38.4 kDa*, expressed in a HEK293 expression system. This protein acts as a receptor for CD47; a.a. 27-370 correspond to the extracellular portion of SIRP-α. *Note: SIRP-α is heavily glycosylated, resulting in apparent higher molecular weight.

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Synonyms

CD172A, Tyrosine-protein phosphatase non-receptor type substrate 1, CD172a, Bit, and MyD-1

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

HEK293

Purity

≥90%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.4 mM KCl, and 20% glycerol

38.4 kDa

Amino Acids

27-370

Genbank #

NM_080792

UniProt #

P78324

Tag(s)

C-terminal His-tag

References

1. Hatherley, D., et al., Mol. Cell, 2008, 31:266-77
2. Baba, N., et al., J. Exp. Med., 2013, 210(6):1251-63

Storage/Stability

>6 months at -80°C

Instructions for Use

Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.

Applications

Useful for studying protein binding and screening small molecules.

Shipping Temperature

-80°C (dry ice)

Notes

The aggregation state of this product has been confirmed to be <10%.

Warnings

Avoid freeze/thaw cycles. Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.

Scientific Category

Cell Surface Receptor

Regulatory Status

Research Use Only

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Datasheets/Protocols

71145_Lot_140331.pdf

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