SHP-2, His-Tag Recombinant

Catalog #
79018
$385 *
Size: 20 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
Purchase
Description

Human recombinant SHP-2 (Src homology domain 2 containing tyrosine phosphatase, also known as protein tyrosine phosphatase N11, PTPN11), full length encompassing amino acids 2-593 (end). This construct contains an N-terminal His-tag (6xHis). The recombinant protein was affinity purified and tested for activity.

This product has been cited 1 time.

Synonyms
SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433, SHP
Product Info
Storage and Usage
Citations1
Species
Human
Host Species/Expression System
E. coli
Purity

≥80%

Format
Aqueous buffer solution
Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.

MW
70 kDa
Amino Acids
2-593
Specific Activity

≥50 pmol/min/µg

Genbank #
NM_002834
UniProt #
Q06124
Tag(s)
N-terminal His-tag
Background
Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.