SHP-1 (PTPN6), GST-Tag (1-577) Recombinant

Catalog #
30021
$325 *
Size: 50 µg
Qty
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Description

Protein tyrosine phosphatase SHP-1, also known as PTPN6 (GenBank accession number NM_080549), a.a. 1-577, with N-terminal GST-tag, MW=93 kDa, expressed in an E. coli expression system.

Synonyms
SHP1; SHP-1; HCP; HCPH; HPTP1C; PTP-1C; SHP-1L; SH-PTP1, SHP
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
MW
93 kDa
Amino Acids
1-577
Specific Activity
1 U/µg
Unit Definition

One unit will hydrolyze 1 pmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.

Genbank #
NM_080549
UniProt #
P29350
Tag(s)
N-terminal GST-tag
Background
PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
References
1. N.E. Kilgore et al., J. Immunol. 2003, 170:4891-4895.
2. J.V. Ravetch & L.L. Lanier Science 2000, 290: 84-9.
3. C. Duchesne et al. J. Biol. Chem 2003, 278:14274-14283.