Scriptaid

Catalog #

27200

$115 *

Size: 1 mg

Qty

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Description

Scriptaid, also known as GCK 1026, is a histone deacetylase inhibitor with optimal concentration of 6-8 µM in a cell based assay. Scriptaid is exhibits lower toxicity than trichostatin A. Scriptaid inhibits tumor growth in vitro and in vivo. It also induces cell cycle arrest in colon cancer cells in culture.

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Synonyms

Scriptaid, GCK 1026

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC.

Format

White to off-white crystalline solid

Formula

C₁₈H₁₈N₂O₄

326.4 Da

Solubility

Solubility in DMSO and DMF is 2.5 mg/ml. Sparingly soluble in aqueous buffers. For maximum solubility, dissolve first in DMF and then dilute with aqueous buffer of choice.

Biological Activity

Inhibits HDAC1 and HDAC3 with an IC50 value ~0.6 µM. Also inhibits HDAC8 with an IC50 ~ 1 µM.

CAS Registry #

287383-59-9

References

1. Su, G.H., et al., Cancer Res. 2010; 60: 3137-3142.
2. Keen, J.C., et al., Cancer Res. Treat. 2003; 81: 177-186.
3. Lee, E.J., et al., Int. J. Oncol. 2008; 33: 767-776.

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