OX40 Screening Services

Tumor necrosis factor receptor superfamily member 4, or OX40, is an immune co-stimulatory receptor. When OX40 is bound to its ligand, OX40L, signals are transmitted that serve to enhance survival of immune cells and increase pro-inflammatory signaling. 

OX40 has been linked to different types of autoimmune and inflammatory diseases. OX40 is also a promising immunotherapy target because stimulation of OX40 has been implicated as a potential treatment for various types of cancer and infectious diseases. In fact, some studies have found that OX40 agonists can promote tumor-free survival in preclinical studies. Therefore, this signaling pathway is an important target for both immuno oncology and anti-inflammatory therapeutic intervention.

BPS Bioscience offers an OX40 [Biotinylated]:OX40L Inhibitor Screening Assay Kit. This assay kit achieves high levels of sensitivity for the detection of OX40:OX40L binding.. Biotin-labeled OX40 is incubated with OX40L and then treated with streptavidin-HRP. When an HRP substrate is added, chemiluminescence is produced. The results of this assay are measured through a chemiluminescence reader. It serves as an excellent first-pass screen for identifying and characterizing inhibitors of OX40:OX40L binding before further mechanistic screens are performed.

In addition to this assay kit, BPS offers OX40 screening and profiling services. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:

• Screen for inhibitors/targets using our OX40:OX40L assay
• Select from IC50 determination and single point concentrations
• Receive data within days of compound submission
• Perform follow-up studies using the same soluble receptors manufactured in-house
• Get questions answered or project guidance in a time-efficient manner

We also offer custom assays for several other immunotherapy targets. Our Custom Assay Development Services allow for flexibility to meet your specific research needs.