KEAP1 - Nrf2 Screening Services
Through BPS Bioscience's KEAP1-Nrf2 screening services, we can help accelerate your research and drug discovery programs.
Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:
- Screen for inhibitors/targets using our KEAP1- Nrf2 assay
- Select from IC50 determination and single point concentrations
- Receive data within days of compound submission
- Perform follow-up studies using the same soluble receptors manufactured in-house
- Get questions answered or project guidance in a time-efficient manner
Contact us today to learn more about our KEAP1 screening services. BPS also offers a variety of KEAP1 related products; the KEAP1-Nrf2 Inhibitor Screening Assay Kit, KEAP1 Protein, and a KEAP1: Nrf2 peptide inhibitor.
The nuclear factor erythroid 2-related factor (Nrf2) is a transcription factor that induces the expression of antioxidant and phase II proteins by binding to the ARE (antioxidant response element) region of the gene promoter. Under basal conditions, Nrf2 is retained in the cytosol by binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress and other ARE activators, Nrf2 is released from Keap1. It then translocates to the nucleus, where it can bind to the ARE and activate expression of antioxidant and phase II proteins that protect the cell from oxidative damage. Because Nrf2 activation leads to a coordinated antioxidant and antiinflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.
Not quite what you’re looking for?
BPS offers Cell-Based Immunotherapy Assay Screening Services for certain Immunotherapy targets. In addition, our Custom Assay Development Services allow for flexibility to meet your specific research needs.
Connect With BPS