SAHA (Vorinostat)
Catalog #
27006
$190
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Description
Soruberoylanilide Hydroxamic Acid (SAHA), or Vorinostat, is a histone deacetylase inhibitor and causes growth arrest and death of some transformed cells both in vitro and in vivo, with little or no toxic effects on normal cells.
This product has been cited 5 times.
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Synonyms
SAHA, Vorinostat
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Product Data Gallery
Product Info
Storage and Usage
Citations5
Purity
≥95% by HPLC.
Format
White to off-white crystalline solid; granular or powder.
Formula
C14H20N2O3
MW
264.3 Da
Solubility
Soluble in DMSO at 66 mg/ml; soluble in ethanol at 2 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50
µM
Biological Activity
SAHA inhibits HDAC1 with IC50 of 40.6 nM using the BPS Bioscience Fluorogenic HDAC Assay Kit (Cat. # 50033).
CAS Registry #
149647-78-9
References
1. Marks, P.A. Oncogene. 26:1351 – 1356 (2007)
2. Cang, S., et al., J. Hematol. Oncol. 2:22 (2009).
3. Zhang, C., et al., J. Invest. Dermatol. 125:1045 – 1052 (2005).
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