(S)-MG132

Catalog #: 27230
Size: 10 mg
$200
MW: 475.6 Da
CAS Registry #: 133407-82-6
Formula: C26H41N3O5
Description:

(S)-MG132, also known as Z-Leu-Leu-Leu-CHO, is a potent, reversible and cell-permeable inhibitor of proteasomes that inhibits cell growth in B16 and IPC227F cells. It also inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis.

Purity:

≥98% by HPLC

Biological Activity:

(S)-MG132 inhibits cell growth in B16 and IPC227F cells with IC50 values of 42 nM and 77 nM, respectively.

Solubility:

Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in these solvents is approximately 25 mg/ml.

Format:
A crystalline solid.
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s):

1. Lee, D.H., et al., Trends Cell Biol. 1998;8:397-403
2. Elliot, P.J., et al., J. Mol. Med. 2003;81:235-245
3. Vivier, M., et al., J. Med. Chem. 2008;51(4):1043-1047

Scientific Category:
Ubiquitin
Product Type:
Inhibitor
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Product Datasheets

27230_Lot_130820.pdf