Catalog #: 27208
Size: 1 mg
MW: 312.4 Da
CAS Registry #: 935881-37-1
Formula: C8H20N2O3
(S)-HDAC-42 is a strong inhibitor of HDACs. It decreases the viability of prostate cancer cell lines by increasingthe expression of p21 and the acetylation of histone H3 while decreasing Akt phosphorylation and Bcl-XL expression. The inhibitor suppresses the growth of PC-3 tumor xenografts, reducing levels of phospho-Akt and Bcl-XL protein in tumors.

≥95% by HPLC

Biological Activity:
(S)-HDAC-42 inhibits HDACs with IC50 = 16 nM in vitro.
Soluble in ethanol, DMSO and DMF, which should be purged with an inert gas. Solubility in these solvents is ~20 mg/ml. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.
A crystalline solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
1. Lu, Q., et al., J. Med. Chem. 2005; 48: 5530-5535
2. Kulp, S.K., et al., Clin. Cancer Res. 2006; 12(17): 5119-5206.
Scientific Category:
Product Type:
Data shown is lot-specific. Contact us for specific information on other lots.

Quality Assurance

Product Datasheets