(S)-HDAC-42

Catalog #: 27208
Size: 1 mg
$100
MW: 312.4 Da
CAS Registry #: 935881-37-1
Formula: C8H20N2O3
Description:
(S)-HDAC-42 is a strong inhibitor of HDACs. It decreases the viability of prostate cancer cell lines by increasingthe expression of p21 and the acetylation of histone H3 while decreasing Akt phosphorylation and Bcl-XL expression. The inhibitor suppresses the growth of PC-3 tumor xenografts, reducing levels of phospho-Akt and Bcl-XL protein in tumors.
Purity:

≥95% by HPLC

Biological Activity:
(S)-HDAC-42 inhibits HDACs with IC50 = 16 nM in vitro.
Solubility:
Soluble in ethanol, DMSO and DMF, which should be purged with an inert gas. Solubility in these solvents is ~20 mg/ml. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.
Format:
A crystalline solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Lu, Q., et al., J. Med. Chem. 2005; 48: 5530-5535
2. Kulp, S.K., et al., Clin. Cancer Res. 2006; 12(17): 5119-5206.
Scientific Category:
HDAC
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.

Quality Assurance

Product Datasheets

27208_Lot120524.pdf