ROR1, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled Recombinant

Catalog #

79482

$435 *

Size: 50 µg

Qty

Bulk/Custom

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Description

Human ROR1, also known as receptor tyrosine kinase-like orphan receptor 1, neurotrophic tyrosine kinase, and receptor-related 1 (NTRKR1), GenBank Accession No. NM_005012, a.a 24-403, with C-terminal Avi-Tag^TM fused to the Fc portion of Human IgG1 and expressed in a HEK293 cell expression system. MW = 71 kDa. This protein runs at a higher apparent M.W. by SDS-PAGE due to glycosylation. This protein is enzymatically biotinylated using Avi-Tag^TM technology.

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Synonyms

receptor tyrosine kinase-like orphan receptor 1, neurotrophic tyrosine kinase, receptor-related 1 NTRKR1, ROR-1

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Gel Filtration Curve

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

HEK293

Purity

≥90%

Format

Aqueous buffer solution

Formulation

8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

71 kDa

Amino Acids

24-403

Genbank #

NM_005012

UniProt #

Q01973

Tag(s)

C-terminal Fc-Avi-Tag

Background

ROR1 is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors that play a role in the control of most basic cellular processes including cell proliferation, differentiation, migration and metabolism. Many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma is associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice.

References

1. Fukuda, T., et al., PNAS. 2007 Dec; 105(8): 3047-3052.

2. Hudecek, M., et al., Clinical Cancer Research. 2013 Jun; 19(12): 3109.